Title: Ch. 4.2.1
Course: Lab Safety > Section: Day 3

Chronic Toxicity quiz adapted from Laboratory Safety by Hill and Finister 2010 by Wiley

Q: The likelihood of suffering an adverse, chronic effect while working with chemicals in undergraduate laboratories is
- Small, because almost no chronic substances are allowed in labs
- Small, because chronic exposure in academic labs is unlikely
- Moderate, because academic labs take few precautions against exposure to chronic toxins
- Large, but we don't know how large since all of the effects are delayed
A: Small, because chronic exposure in academic labs is unlikely

Q: Which of the following statements is true?  Select all that apply.
- Acute toxicity does not predict ahronic toxicity
- We know much more about acute toxicity than we do about chronic toxicity
- Studies that evaluate chronic toxicity are very expensive
- None are true
A: Acute toxicity does not predict ahronic toxicity; We know much more about acute toxicity than we do about chronic toxicity; Studies that evaluate chronic toxicity are very expensive

Q: Chronic toxicity studies:  (Select all that apply)
- Are sometimes not conducted because we don't know what symptom or effect to measure
- Sometime occur based on the accidental exposure of a group of people to a chemical
- Are usually more definitive in establishing a cause-effect relationship than acute toxicity studies
- Are often based on serendipitious obsevations
A: Are sometimes not conducted because we don't know what symptom or effect to measure; Sometime occur based on the accidental exposure of a group of people to a chemical; Are often based on serendipitious obsevations

Q: It is known that we ingest small amounts of large numbers of synthetic and naturally occurring chronically toxic compounds regularly
- And this accounts for the relatively high cancer rate in the United States
- But since the toxic effects of these substances are not detected it is clear that the body's defense systems can usually handle these chemical assaults
- But the delay time between ingestion and illness is predicted to be over 80 years, so the effects are rarely seen
- But the effect of these compounds is masked by other illnesses
A: But since the toxic effects of these substances are not detected it is clear that the body's defense systems can usually handle these chemical assaults

Q: Which of the following factors are the primary causes of chronic disease?  Select all that apply.
- Genetics
- Lifestyle choices
- Age
- Chemicals
A: Genetics; Lifestyle choices; Age

Q: The element mercury
- Is much more toxic by ingestion than inhalation
- Produces symptoms as soon as blood level concentration rise to detectable levels
- Was widely used in laboratories in the 20th century where spills of the liquid Hg occurred and exposed chemists to Hg vapors
- Is the preferred liquid in thermometers because it is so chemically inert
A: Was widely used in laboratories in the 20th century where spills of the liquid Hg occurred and exposed chemists to Hg vapors

Q: The Laboratory Standard (OSHA 29 CFR 1910.1450)
- Ignores the issue of chronic toxicity because it is so rare in chemistry labs
- Regulates the specifci levels of known chronic toxicants
- Requires that scientist be aware of risks and hazards associated with chronic toxicants
- Requires tha the ACGIH determines the TLVs for all chronic toxicants
A: Requires that scientist be aware of risks and hazards associated with chronic toxicants