Title: Module 6 Genetics
Course: DEH 2400 Oral Pathology > Section: Module 6 Genetics

Introduction

Genetics is the study of genes and inherited traits. Changes in the DNA or chromosomes of cells cause genetic conditions to occur. Some common genetic conditions, many of which have oral manifestations will be presented in this module. The different patterns of inheritance, chromosomal abnormalities, and inherited disorders that affect the oral cavity and surrounding structures will also be presented.
The dental hygienist should be knowledgeable of common genetic conditions that affect the oral cavity and surrounding structures.

Objectives

After completing this module the student will be able to:

- State the purpose of mitosis and meiosis
- List the four inheritance patterns and list the four types of amelogenesis imperfecta
- Compare and contrast dentiogenesis imperfecta, amelogenesis imperfecta, and dentin dysplasia, including the inheritance patterns, the clinical manifestations, and the radiographic appearance of each.
- State the inheritance pattern and describe the oral manifestations for each of the following: cyclic neutropenia, Papillon-Lefèvre syndrome, cherubism, Ellis–van Creveld syndrome, mandibulofacial dysostosis (Treacher Collins syndrome), osteogenesis imperfecta, hereditary hemorrhagic telangiectasia (Osler-Rendu–Parkes Weber syndrome), Peutz-Jeghers syndrome, white sponge nevus (Cannon disease), hypohidrotic ectodermal dysplasia, hypophosphatasia, and hypophosphatemic vitamin D—resistant rickets.
- State the type and location of the malignancy associated with each of the following syndromes: Gardner syndrome; nevoid basal cell carcinoma syndrome (Gorlin syndrome); multiple mucosal neuromas, medullary carcinoma of the thyroid gland, and pheochromocytoma syndrome (multiple endocrine neoplasia type 2B [MEN 2B]); and neurofibromatosis of von Recklinghausen.

Reading and Resources

Textbook: Genetics pp. 196-231
Video: Faces of Turner Syndrome http://www.youtube.com/watch?v=PftPlnJtRE8
Video: Bill Nye Genes, DNA, and Chromosomes http://www.youtube.com/watch?v=V9BZ3zx8b8I